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KMID : 0378019730160020069
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New Medical Journal
1973 Volume.16 No. 2 p.69 ~ p.77
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Effect of Cantharides Extract in Mice Intestinal Mucous Cell
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Abstract
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In order to study the effect of cantharides extract on the mucous cell in the mice intestine, the experimental animals were injected with 0.04 mg. per gm. body weight of cantharides extract through intraperitoneally. They were sacrificed by ether anesthesia and obtained from distal and proximal portions of the small intestine and colon, and fixed in 10% neutral formol. After embedded in paraffin, sectioned in 7 micra thickness, and stained with PAS (periodic acid Schiff´s) reaction. The average number of the mucous cell was counted in each specimen over 10 fields under 450 magnification.
The following results were obtained;
1. The average number of mucous cell decreased from 1 hr. after injection, and were reduced progressively by time lapsed.
2. The average number of mucous cell showed the lowest value at 48 brs. and began increase at 96 hrs. after injection.
3. The normal mucous cell (A and B types) decreased with lapse of time after injection, but mature discharged cell (C -type) increased.
4. According to the above findings, it is presumed that cantharides extract accelerate discharge of mucin in mature mucous cells but inhibit the production of mucin in growing mucous cells.
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